Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome
Association of Lipid Profile and Inflammatory Markers With COVID-19 Severity and Outcome
Blog Article
Background: COVID-19 is a highly contagious disease that has already affected millions of people worldwide.Proinflammatory cytokines in COVID-19 infection change lipid metabolism and profile.This study investigates the association between lipid profile and inflammatory markers with the severity and outcome of COVID-19 patients referred to a teaching hospital in acure face lotion Mazandaran Province, Iran, during April-May and July-August 2020.
Methods: This study was conducted on 140 patients with COVID-19 based on their clinical symptoms, imaging results, and laboratory findings.Patients were categorized as severe and non-severe groups based on the Centers for Disease Control and Prevention criteria.Blood samples (5-7 mL) were collected from patients after 12 hours of fasting.
Serum triglycerides, cholesterol, highdensity lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured using Pars Azmoon Kits (Hitachi Ltd).Results: Of 140 COVID-19 patients, 33.57% had severe and 66.
43% had non-severe disease.Patients with severe disease had a significantly lower mean LDL serum level than those with non-severe involvement (56.39±3.
62 vs 70.10±3.74 mg/dL) (P=0.
023).Patients in the intensive care units had significantly lower HDL, LDL, and cholesterol serum g35 coupe fender levels than those hospitalized in other parts (P=0.006, P=0.
002, and P=0.002, respectively).There was a significant negative correlation between HDL serum level and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) (P=0.
0001 and r=-0.482) and (P=0.01 and r=-0.
258), respectively.Additionally, there was a significant correlation between cholesterol level and CRP, triglycerides, and ESR (P=0.016 and P=0.
02, respectively).Conclusion: The present study highlights the potential of lipid profiling as a cost-effective and accessible marker to assess COVID-19 severity and prognosis.